Show All PubMed™ References (207 found)

20622858 PubMed
Albizu L, Cottet M, Kralikova M, Stoev S, Seyer R, Brabet I, Roux T, Bazin H, Bourrier E, Lamarque L, Breton C, Rives ML, Newman A, Javitch J, Trinquet E, Manning M, Pin JP, Mouillac B, and Durroux T. Time-resolved FRET between GPCR ligands reveals oligomers in native tissues. Nat Chem Biol (2010 Jul 11): .
20080658 PubMed
Rivero-Muller A, Chou YY, Ji I, Lajic S, Hanyaloglu AC, Jonas K, Rahman N, Ji TH, and Huhtaniemi I. Rescue of defective G protein-coupled receptor function in vivo by intermolecular cooperation. Proc Natl Acad Sci U S A (2010 Jan 11): .
19837905 PubMed
Hudson BD, Hebert TE, and Kelly ME. Ligand- and heterodimer-directed signaling of the CB(1) cannabinoid receptor. Mol Pharmacol 77 (2010 Jan): 1-9.
19799451 PubMed
Dunham JH, Meyer RC, Garcia EL, and Hall RA. GPR37 surface expression enhancement via N-terminal truncation or protein-protein interactions. Biochemistry 48 (2009 Nov 3): 10286-97.
19652957 PubMed
Uriguen L, Garcia-Fuster MJ, Callado LF, Morentin B, La Harpe R, Casado V, Lluis C, Franco R, Garcia-Sevilla JA, and Meana JJ. Immunodensity and mRNA expression of A2A adenosine, D2 dopamine, and CB1 cannabinoid receptors in postmortem frontal cortex of subjects with schizophrenia: effect of antipsychotic treatment. Psychopharmacology (Berl) 206 (2009 Oct): 313-24.
19627447 PubMed
Tebano MT, Martire A, Chiodi V, Pepponi R, Ferrante A, Domenici MR, Frank C, Chen JF, Ledent C, and Popoli P. Adenosine A2A receptors enable the synaptic effects of cannabinoid CB1 receptors in the rodent striatum. J Neurochem 110 (2009 Sep): 1921-30.
19429716 PubMed
Gao F, Harikumar KG, Dong M, Lam PC, Sexton PM, Christopoulos A, Bordner A, Abagyan R, and Miller LJ. Functional importance of a structurally distinct homodimeric complex of the family B G protein-coupled secretin receptor. Mol Pharmacol 76 (2009 Aug): 264-74.
19524516 PubMed
Scherrer G, Imamachi N, Cao YQ, Contet C, Mennicken F, O'Donnell D, Kieffer BL, and Basbaum AI. Dissociation of the opioid receptor mechanisms that control mechanical and heat pain. Cell 137 (2009 Jun 12): 1148-59.
19279328 PubMed
Brea J, Castro M, Giraldo J, Lopez-Gimenez JF, Padin JF, Quintian F, Cadavid MI, Vilaro MT, Mengod G, Berg KA, Clarke WP, Vilardaga JP, Milligan G, and Loza MI. Evidence for distinct antagonist-revealed functional states of 5-hydroxytryptamine(2A) receptor homodimers. Mol Pharmacol 75 (2009 Jun): 1380-91.
19344374 PubMed
Cabello N, Gandia J, Bertarelli DC, Watanabe M, Lluis C, Franco R, Ferre S, Lujan R, and Ciruela F. Metabotropic glutamate type 5, dopamine D2 and adenosine A2a receptors form higher-order oligomers in living cells. J Neurochem 109 (2009 Jun): 1497-507.
19413572 PubMed
Ferrada C, Moreno E, Casado V, Bongers G, Cortes A, Mallol J, Canela EI, Leurs R, Ferre S, Lluis C, and Franco R. Marked changes in signal transduction upon heteromerization of dopamine D1 and histamine H3 receptors. Br J Pharmacol 157 (2009 May): 64-75.
19171671 PubMed
So CH, Verma V, Alijaniaram M, Cheng R, Rashid AJ, O'Dowd BF, and George SR. Calcium signaling by dopamine D5 receptor and D5-D2 receptor hetero-oligomers occurs by a mechanism distinct from that for dopamine D1-D2 receptor hetero-oligomers. Mol Pharmacol 75 (2009 Apr): 843-54.
19234451 PubMed
Dorsch S, Klotz KN, Engelhardt S, Lohse MJ, and Bunemann M. Analysis of receptor oligomerization by FRAP microscopy. Nat Methods 6 (2009 Mar): 225-30.
19186134 PubMed
Harding PJ, Attrill H, Boehringer J, Ross S, Wadhams GH, Smith E, Armitage JP, and Watts A. Constitutive dimerization of the G-protein coupled receptor, neurotensin receptor 1, reconstituted into phospholipid bilayers. Biophys J 96 (2009 Feb): 964-73.
19401177 PubMed
Rasmussen BA, Kim E, Unterwald EM, and Rawls SM. Methanandamide attenuates cocaine-induced hyperthermia in rats by a cannabinoid CB(1)-dopamine D(2) receptor mechanism. Brain Res (2009 Jan 17): .
19017652 PubMed
Hansen JL, Hansen JT, Speerschneider T, Lyngso C, Erikstrup N, Burstein ES, Weiner DM, Walther T, Makita N, Iiri T, Merten N, Kostenis E, and Sheikh SP. Lack of evidence for AT1R/B2R heterodimerization in COS-7, HEK293, and NIH3T3 cells: how common is the AT1R/B2R heterodimer? J Biol Chem 284 (2009 Jan 16): 1831-9.
18691604 PubMed
Ferre S, Goldberg SR, Lluis C, and Franco R. Looking for the role of cannabinoid receptor heteromers in striatal function. Neuropharmacology 56 Suppl 1 (2009): 226-34.
18764782 PubMed
Canals M, Lopez-Gimenez JF, and Milligan G. Cell surface delivery and structural re-organization by pharmacological chaperones of an oligomerization-defective alpha(1b)-adrenoceptor mutant demonstrates membrane targeting of GPCR oligomers. Biochem J 417 (2009 Jan 1): 161-72.
19013155 PubMed
Vidi PA, Chen J, Irudayaraj JM, and Watts VJ. Adenosine A(2A) receptors assemble into higher-order oligomers at the plasma membrane. FEBS Lett 582 (2008 Dec 10): 3985-90.
18823943 PubMed
Vischer HF, Nijmeijer S, Smit MJ, and Leurs R. Viral hijacking of human receptors through heterodimerization. Biochem Biophys Res Commun 377 (2008 Dec 5): 93-7.
18401761 PubMed
Harikumar KG, Morfis MM, Sexton PM, and Miller LJ. Pattern of intra-family hetero-oligomerization involving the G-protein-coupled secretin receptor. J Mol Neurosci 36 (2008 Nov): 279-85.
18836069 PubMed
Decaillot FM, Rozenfeld R, Gupta A, and Devi LA. Cell surface targeting of mu-delta opioid receptor heterodimers by RTP4. Proc Natl Acad Sci U S A 105 (2008 Oct 14): 16045-50.
18644790 PubMed
Marcellino D, Ferre S, Casado V, Cortes A, Le Foll B, Mazzola C, Drago F, Saur O, Stark H, Soriano A, Barnes C, Goldberg SR, Lluis C, Fuxe K, and Franco R. Identification of dopamine D1-D3 receptor heteromers. Indications for a role of synergistic D1-D3 receptor interactions in the striatum. J Biol Chem 283 (2008 Sep 19): 26016-25.
18668123 PubMed
Guo W, Urizar E, Kralikova M, Mobarec JC, Shi L, Filizola M, and Javitch JA. Dopamine D2 receptors form higher order oligomers at physiological expression levels. EMBO J 27 (2008 Sep 3): 2293-304.
18675812 PubMed
Gandia J, Galino J, Amaral OB, Soriano A, Lluis C, Franco R, and Ciruela F. Detection of higher-order G protein-coupled receptor oligomers by a combined BRET-BiFC technique. FEBS Lett 582 (2008 Sep 3): 2979-84.
18524886 PubMed
Vidi PA, Chemel BR, Hu CD, and Watts VJ. Ligand-dependent oligomerization of dopamine D(2) and adenosine A(2A) receptors in living neuronal cells. Mol Pharmacol 74 (2008 Sep): 544-51.
18627772 PubMed
Kumpost J, Syrova Z, Kulihova L, Frankova D, Bologna JC, Hlavackova V, Prezeau L, Kralikova M, Hruskova B, Pin JP, and Blahos J. Surface expression of metabotropic glutamate receptor variants mGluR1a and mGluR1b in transfected HEK293 cells. Neuropharmacology 55 (2008 Sep): 409-18.
18521575 PubMed
Natesan S, Reckless GE, Barlow KB, Odontiadis J, Nobrega JN, Baker GB, George SR, Mamo D, and Kapur S. The antipsychotic potential of l-stepholidine--a naturally occurring dopamine receptor D1 agonist and D2 antagonist. Psychopharmacology (Berl) 199 (2008 Aug): 275-89.
18547596 PubMed
Ferrada C, Ferre S, Casado V, Cortes A, Justinova Z, Barnes C, Canela EI, Goldberg SR, Leurs R, Lluis C, and Franco R. Interactions between histamine H3 and dopamine D2 receptors and the implications for striatal function. Neuropharmacology 55 (2008 Aug): 190-7.
18627138 PubMed
Casciari D, Dell'Orco D, and Fanelli F. Homodimerization of neurotensin 1 receptor involves helices 1, 2, and 4: insights from quaternary structure predictions and dimerization free energy estimations. J Chem Inf Model 48 (2008 Aug): 1669-78.
18490452 PubMed
Damian M, Mary S, Martin A, Pin JP, and Baneres JL. G protein activation by the leukotriene B4 receptor dimer. Evidence for an absence of trans-activation. J Biol Chem 283 (2008 Jul 25): 21084-92.
18533278 PubMed
Finley MJ, Chen X, Bardi G, Davey P, Geller EB, Zhang L, Adler MW, and Rogers TJ. Bi-directional heterologous desensitization between the major HIV-1 co-receptor CXCR4 and the kappa-opioid receptor. J Neuroimmunol 197 (2008 Jul 15): 114-23.
18614679 PubMed
Dittman JS, and Kaplan JM. Behavioral impact of neurotransmitter-activated G-protein-coupled receptors: muscarinic and GABAB receptors regulate Caenorhabditis elegans locomotion. J Neurosci 28 (2008 Jul 9): 7104-12.
18424554 PubMed
Fiorentini C, Busi C, Gorruso E, Gotti C, Spano P, and Missale C. Reciprocal regulation of dopamine D1 and D3 receptor function and trafficking by heterodimerization. Mol Pharmacol 74 (2008 Jul): 59-69.
18481853 PubMed
Assadi-Porter FM, Tonelli M, Maillet E, Hallenga K, Benard O, Max M, and Markley JL. Direct NMR detection of the binding of functional ligands to the human sweet receptor, a heterodimeric family 3 GPCR. J Am Chem Soc 130 (2008 Jun 11): 7212-3.
17957223 PubMed
Martin AB, Fernandez-Espejo E, Ferrer B, Gorriti MA, Bilbao A, Navarro M, Rodriguez de Fonseca F, and Moratalla R. Expression and function of CB1 receptor in the rat striatum: localization and effects on D1 and D2 dopamine receptor-mediated motor behaviors. Neuropsychopharmacology 33 (2008 Jun): 1667-79.
18307412 PubMed
Parenty G, Appelbe S, and Milligan G. CXCR2 chemokine receptor antagonism enhances DOP opioid receptor function via allosteric regulation of the CXCR2-DOP receptor heterodimer. Biochem J 412 (2008 Jun 1): 245-56.
18488035 PubMed
Maurel D, Comps-Agrar L, Brock C, Rives ML, Bourrier E, Ayoub MA, Bazin H, Tinel N, Durroux T, Prezeau L, Trinquet E, and Pin JP. Cell-surface protein-protein interaction analysis with time-resolved FRET and snap-tag technologies: application to GPCR oligomerization. Nat Methods 5 (2008 Jun): 561-7.
18554293 PubMed
Alen F, Moreno-Sanz G, Isabel de Tena A, Brooks RD, Lopez-Jimenez A, Navarro M, and Lopez-Moreno JA. Pharmacological activation of CB1 and D2 receptors in rats: predominant role of CB1 in the increase of alcohol relapse. Eur J Neurosci 27 (2008 Jun): 3292-8.
18388862 PubMed
Rondard P, Huang S, Monnier C, Tu H, Blanchard B, Oueslati N, Malhaire F, Li Y, Trinquet E, Labesse G, Pin JP, and Liu J. Functioning of the dimeric GABA(B) receptor extracellular domain revealed by glycan wedge scanning. EMBO J 27 (2008 May 7): 1321-32.
17963239 PubMed
Niv MY, and Filizola M. Influence of oligomerization on the dynamics of G-protein coupled receptors as assessed by normal mode analysis. Proteins 71 (2008 May 1): 575-86.
18178645 PubMed
Taylor MS, Fung HK, Rajgaria R, Filizola M, Weinstein H, and Floudas CA. Mutations affecting the oligomerization interface of G-protein-coupled receptors revealed by a novel de novo protein design framework. Biophys J 94 (2008 Apr 1): 2470-81.
18262573 PubMed
Marcellino D, Carriba P, Filip M, Borgkvist A, Frankowska M, Bellido I, Tanganelli S, Muller CE, Fisone G, Lluis C, Agnati LF, Franco R, and Fuxe K. Antagonistic cannabinoid CB1/dopamine D2 receptor interactions in striatal CB1/D2 heteromers. A combined neurochemical and behavioral analysis. Neuropharmacology 54 (2008 Apr): 815-23.
18344975 PubMed
Mancia F, Assur Z, Herman AG, Siegel R, and Hendrickson WA. Ligand sensitivity in dimeric associations of the serotonin 5HT2c receptor. EMBO Rep 9 (2008 Apr): 363-9.
18237729 PubMed
Juhasz JR, Hasbi A, Rashid AJ, So CH, George SR, and O'Dowd BF. Mu-opioid receptor heterooligomer formation with the dopamine D1 receptor as directly visualized in living cells. Eur J Pharmacol 581 (2008 Mar 10): 235-43.
18297054 PubMed
Gonzalez-Maeso J, Ang RL, Yuen T, Chan P, Weisstaub NV, Lopez-Gimenez JF, Zhou M, Okawa Y, Callado LF, Milligan G, Gingrich JA, Filizola M, Meana JJ, and Sealfon SC. Identification of a serotonin/glutamate receptor complex implicated in psychosis. Nature 452 (2008 Mar 6): 93-7.
17517168 PubMed
Adams CL, Cowen MS, Short JL, and Lawrence AJ. Combined antagonism of glutamate mGlu5 and adenosine A2A receptors interact to regulate alcohol-seeking in rats. Int J Neuropsychopharmacol 11 (2008 Mar): 229-41.
18063691 PubMed
Svendsen AM, Vrecl M, Ellis TM, Heding A, Kristensen JB, Wade JD, Bathgate RA, De Meyts P, and Nohr J. Cooperative binding of insulin-like Peptide 3 to a dimeric relaxin family peptide receptor 2. Endocrinology 149 (2008 Mar): 1113-20.
18193048 PubMed
Vilardaga JP, Nikolaev VO, Lorenz K, Ferrandon S, Zhuang Z, and Lohse MJ. Conformational cross-talk between alpha2A-adrenergic and mu-opioid receptors controls cell signaling. Nat Chem Biol 4 (2008 Feb): 126-31.
18200497 PubMed
Pello OM, Martinez-Munoz L, Parrillas V, Serrano A, Rodriguez-Frade JM, Toro MJ, Lucas P, Monterrubio M, Martinez-A C, and Mellado M. Ligand stabilization of CXCR4/delta-opioid receptor heterodimers reveals a mechanism for immune response regulation. Eur J Immunol 38 (2008 Feb): 537-49.
18682799 PubMed
Cook BL, Ernberg KE, Chung H, and Zhang S. Study of a synthetic human olfactory receptor 17-4: expression and purification from an inducible mammalian cell line. PLoS One 3 (2008): e2920.
18956124 PubMed
Navarro G, Carriba P, Gandia J, Ciruela F, Casado V, Cortes A, Mallol J, Canela EI, Lluis C, and Franco R. Detection of heteromers formed by cannabinoid CB1, dopamine D2, and adenosine A2A G-protein-coupled receptors by combining bimolecular fluorescence complementation and bioluminescence energy transfer. ScientificWorldJournal 8 (2008): 1088-97.
17941650 PubMed
Hasbi A, Nguyen T, Fan T, Cheng R, Rashid A, Alijaniaram M, Rasenick MM, O'Dowd BF, and George SR. Trafficking of preassembled opioid mu-delta heterooligomer-Gz signaling complexes to the plasma membrane: coregulation by agonists. Biochemistry 46 (2007 Nov 13): 12997-3009.
17855348 PubMed
Brock C, Oueslati N, Soler S, Boudier L, Rondard P, and Pin JP. Activation of a dimeric metabotropic glutamate receptor by intersubunit rearrangement. J Biol Chem 282 (2007 Nov 9): 33000-8.
17356572 PubMed
Carriba P, Ortiz O, Patkar K, Justinova Z, Stroik J, Themann A, Muller C, Woods AS, Hope BT, Ciruela F, Casado V, Canela EI, Lluis C, Goldberg SR, Moratalla R, Franco R, and Ferre S. Striatal adenosine A2A and cannabinoid CB1 receptors form functional heteromeric complexes that mediate the motor effects of cannabinoids. Neuropsychopharmacology 32 (2007 Nov): 2249-59.
17785463 PubMed
Heroux M, Hogue M, Lemieux S, and Bouvier M. Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1. J Biol Chem 282 (2007 Oct 26): 31610-20.
17715128 PubMed
Sohy D, Parmentier M, and Springael JY. Allosteric transinhibition by specific antagonists in CCR2/CXCR4 heterodimers. J Biol Chem 282 (2007 Oct 12): 30062-9.
17561373 PubMed
Sartania N, Appelbe S, Pediani JD, and Milligan G. Agonist occupancy of a single monomeric element is sufficient to cause internalization of the dimeric beta2-adrenoceptor. Cell Signal 19 (2007 Sep): 1928-38.
17384143 PubMed
Rozenfeld R, and Devi LA. Receptor heterodimerization leads to a switch in signaling: beta-arrestin2-mediated ERK activation by mu-delta opioid receptor heterodimers. FASEB J 21 (2007 Aug): 2455-65.
17519357 PubMed
So CH, Verma V, O'Dowd BF, and George SR. Desensitization of the dopamine D1 and D2 receptor hetero-oligomer mediated calcium signal by agonist occupancy of either receptor. Mol Pharmacol 72 (2007 Aug): 450-62.
17620610 PubMed
White JF, Grodnitzky J, Louis JM, Trinh LB, Shiloach J, Gutierrez J, Northup JK, and Grisshammer R. Dimerization of the class A G protein-coupled neurotensin receptor NTS1 alters G protein interaction. Proc Natl Acad Sci U S A 104 (2007 Jul 17): 12199-204.
17901566 PubMed
Lukasiewicz S, Blasiak E, Faron-Gorecka A, Polit A, Tworzydlo M, Gorecki A, Wasylewski Z, and Dziedzicka-Wasylewska M. Fluorescence studies of homooligomerization of adenosine A2A and serotonin 5-HT1A receptors reveal the specificity of receptor interactions in the plasma membrane. Pharmacol Rep 59 (2007 Jul-Aug): 379-92.
17503773 PubMed
Heroux M, Breton B, Hogue M, and Bouvier M. Assembly and signaling of CRLR and RAMP1 complexes assessed by BRET. Biochemistry 46 (2007 Jun 12): 7022-33.
17318384 PubMed
Young SF, Griffante C, and Aguilera G. Dimerization between vasopressin V1b and corticotropin releasing hormone type 1 receptors. Cell Mol Neurobiol 27 (2007 Jun): 439-61.
17374491 PubMed
Lodowski DT, Salom D, Le Trong I, Teller DC, Ballesteros JA, Palczewski K, and Stenkamp RE. Crystal packing analysis of Rhodopsin crystals. J Struct Biol 158 (2007 Jun): 455-62.
17379184 PubMed
Berthouze M, Rivail L, Lucas A, Ayoub MA, Russo O, Sicsic S, Fischmeister R, Berque-Bestel I, Jockers R, and Lezoualc'h F. Two transmembrane Cys residues are involved in 5-HT4 receptor dimerization. Biochem Biophys Res Commun 356 (2007 May 11): 642-7.
17272391 PubMed
Thomas RM, Nechamen CA, Mazurkiewicz JE, Muda M, Palmer S, and Dias JA. Follice-stimulating hormone receptor forms oligomers and shows evidence of carboxyl-terminal proteolytic processing. Endocrinology 148 (2007 May): 1987-95.
17220353 PubMed
Lopez-Gimenez JF, Canals M, Pediani JD, and Milligan G. The alpha1b-adrenoceptor exists as a higher-order oligomer: effective oligomerization is required for receptor maturation, surface delivery, and function. Mol Pharmacol 71 (2007 Apr): 1015-29.
17134677 PubMed
Wilson SJ, McGinley K, Huang AJ, and Smyth EM. Heterodimerization of the alpha and beta isoforms of the human thromboxane receptor enhances isoprostane signaling. Biochem Biophys Res Commun 352 (2007 Jan 12): 397-403.
17194762 PubMed
Rashid AJ, So CH, Kong MM, Furtak T, El-Ghundi M, Cheng R, O'Dowd BF, and George SR. D1-D2 dopamine receptor heterooligomers with unique pharmacology are coupled to rapid activation of Gq/11 in the striatum. Proc Natl Acad Sci U S A 104 (2007 Jan 9): 654-9.
17015451 PubMed
Ellis J, Pediani JD, Canals M, Milasta S, and Milligan G. Orexin-1 receptor-cannabinoid CB1 receptor heterodimerization results in both ligand-dependent and -independent coordinated alterations of receptor localization and function. J Biol Chem 281 (2006 Dec 15): 38812-24.
17139258 PubMed
Damian M, Martin A, Mesnier D, Pin JP, and Baneres JL. Asymmetric conformational changes in a GPCR dimer controlled by G-proteins. EMBO J 25 (2006 Dec 13): 5693-702.
17005232 PubMed
Milligan G, Pediani JD, Canals M, and Lopez-Gimenez JF. Oligomeric structure of the alpha1b-adrenoceptor: comparisons with rhodopsin. Vision Res 46 (2006 Dec): 4434-41.
17086179 PubMed
James JR, Oliveira MI, Carmo AM, Iaboni A, and Davis SJ. A rigorous experimental framework for detecting protein oligomerization using bioluminescence resonance energy transfer. Nat Methods 3 (2006 Dec): 1001-6.
16926282 PubMed
Albizu L, Balestre MN, Breton C, Pin JP, Manning M, Mouillac B, Barberis C, and Durroux T. Probing the existence of G protein-coupled receptor dimers by positive and negative ligand-dependent cooperative binding. Mol Pharmacol 70 (2006 Nov): 1783-91.
17060607 PubMed
Salom D, Lodowski DT, Stenkamp RE, Le Trong I, Golczak M, Jastrzebska B, Harris T, Ballesteros JA, and Palczewski K. Crystal structure of a photoactivated deprotonated intermediate of rhodopsin. Proc Natl Acad Sci U S A 103 (2006 Oct 31): 16123-8.
16857671 PubMed
Herrick-Davis K, Weaver BA, Grinde E, and Mazurkiewicz JE. Serotonin 5-HT2C receptor homodimer biogenesis in the endoplasmic reticulum: real-time visualization with confocal fluorescence resonance energy transfer. J Biol Chem 281 (2006 Sep 15): 27109-16.
16757535 PubMed
Prinster SC, Holmqvist TG, and Hall RA. Alpha2C-adrenergic receptors exhibit enhanced surface expression and signaling upon association with beta2-adrenergic receptors. J Pharmacol Exp Ther 318 (2006 Sep): 974-81.
16787923 PubMed
Rondard P, Liu J, Huang S, Malhaire F, Vol C, Pinault A, Labesse G, and Pin JP. Coupling of agonist binding to effector domain activation in metabotropic glutamate-like receptors. J Biol Chem 281 (2006 Aug 25): 24653-61.
16682504 PubMed
Breit A, Gagnidze K, Devi LA, Lagace M, and Bouvier M. Simultaneous activation of the delta opioid receptor (deltaOR)/sensory neuron-specific receptor-4 (SNSR-4) hetero-oligomer by the mixed bivalent agonist bovine adrenal medulla peptide 22 activates SNSR-4 but inhibits deltaOR signaling. Mol Pharmacol 70 (2006 Aug): 686-96.
16690720 PubMed
Snook LA, Milligan G, Kieffer BL, and Massotte D. Mu-delta opioid receptor functional interaction: Insight using receptor-G protein fusions. J Pharmacol Exp Ther 318 (2006 Aug): 683-90.
16778767 PubMed
Levoye A, Dam J, Ayoub MA, Guillaume JL, Couturier C, Delagrange P, and Jockers R. The orphan GPR50 receptor specifically inhibits MT1 melatonin receptor function through heterodimerization. EMBO J 25 (2006 Jul 12): 3012-23.
16597839 PubMed
Kong MM, Fan T, Varghese G, O'dowd BF, and George SR. Agonist-induced cell surface trafficking of an intracellularly sequestered D1 dopamine receptor homo-oligomer. Mol Pharmacol 70 (2006 Jul): 78-89.
17089205 PubMed
Filizola M, Wang SX, and Weinstein H. Dynamic models of G-protein coupled receptor dimers: indications of asymmetry in the rhodopsin dimer from molecular dynamics simulations in a POPC bilayer. J Comput Aided Mol Des 20 (2006 Jul-Aug): 405-16.
16724110 PubMed
Pontier SM, Lahaie N, Ginham R, St-Gelais F, Bonin H, Bell DJ, Flynn H, Trudeau LE, McIlhinney J, White JH, and Bouvier M. Coordinated action of NSF and PKC regulates GABAB receptor signaling efficacy. EMBO J 25 (2006 Jun 21): 2698-709.
16682964 PubMed
Rios C, Gomes I, and Devi LA. mu opioid and CB1 cannabinoid receptor interactions: reciprocal inhibition of receptor signaling and neuritogenesis. Br J Pharmacol 148 (2006 Jun): 387-95.
16670773 PubMed
McGraw DW, Mihlbachler KA, Schwarb MR, Rahman FF, Small KM, Almoosa KF, and Liggett SB. Airway smooth muscle prostaglandin-EP1 receptors directly modulate beta2-adrenergic receptors within a unique heterodimeric complex. J Clin Invest 116 (2006 May): 1400-9.
16567090 PubMed
Fotiadis D, Jastrzebska B, Philippsen A, Muller DJ, Palczewski K, and Engel A. Structure of the rhodopsin dimer: a working model for G-protein-coupled receptors. Curr Opin Struct Biol 16 (2006 Apr): 252-9.
16440297 PubMed
Pickel VM, Chan J, Kearn CS, and Mackie K. Targeting dopamine D2 and cannabinoid-1 (CB1) receptors in rat nucleus accumbens. J Comp Neurol 495 (2006 Mar 20): 299-313.
16489763 PubMed
Michineau S, Alhenc-Gelas F, and Rajerison RM. Human bradykinin B2 receptor sialylation and N-glycosylation participate with disulfide bonding in surface receptor dimerization. Biochemistry 45 (2006 Feb 28): 2699-707.
16492772 PubMed
Mansoor SE, Palczewski K, and Farrens DL. Rhodopsin self-associates in asolectin liposomes. Proc Natl Acad Sci U S A 103 (2006 Feb 28): 3060-5.
16492774 PubMed
Kota P, Reeves PJ, Rajbhandary UL, and Khorana HG. Opsin is present as dimers in COS1 cells: identification of amino acids at the dimeric interface. Proc Natl Acad Sci U S A 103 (2006 Feb 28): 3054-9.
16481441 PubMed
Ciruela F, Casado V, Rodrigues RJ, Lujan R, Burgueno J, Canals M, Borycz J, Rebola N, Goldberg SR, Mallol J, Cortes A, Canela EI, Lopez-Gimenez JF, Milligan G, Lluis C, Cunha RA, Ferre S, and Franco R. Presynaptic control of striatal glutamatergic neurotransmission by adenosine A1-A2A receptor heteromers. J Neurosci 26 (2006 Feb 15): 2080-7.
16417234 PubMed
Sanchez-Laorden BL, Sanchez-Mas J, Martinez-Alonso E, Martinez-Menarguez JA, Garcia-Borron JC, and Jimenez-Cervantes C. Dimerization of the human melanocortin 1 receptor: functional consequences and dominant-negative effects. J Invest Dermatol 126 (2006 Jan): 172-81.
16365317 PubMed
Daniels DJ, Lenard NR, Etienne CL, Law PY, Roerig SC, and Portoghese PS. Opioid-induced tolerance and dependence in mice is modulated by the distance between pharmacophores in a bivalent ligand series. Proc Natl Acad Sci U S A 102 (2005 Dec 27): 19208-13.
16195233 PubMed
Herrick-Davis K, Grinde E, Harrigan TJ, and Mazurkiewicz JE. Inhibition of serotonin 5-hydroxytryptamine2c receptor function through heterodimerization: receptor dimers bind two molecules of ligand and one G-protein. J Biol Chem 280 (2005 Dec 2): 40144-51.
16301531 PubMed
Guo W, Shi L, Filizola M, Weinstein H, and Javitch JA. Crosstalk in G protein-coupled receptors: changes at the transmembrane homodimer interface determine activation. Proc Natl Acad Sci U S A 102 (2005 Nov 29): 17495-500.
16280580 PubMed
Kachroo A, Orlando LR, Grandy DK, Chen JF, Young AB, and Schwarzschild MA. Interactions between metabotropic glutamate 5 and adenosine A2A receptors in normal and parkinsonian mice. J Neurosci 25 (2005 Nov 9): 10414-9.
15893915 PubMed
Laroche G, Lepine MC, Theriault C, Giguere P, Giguere V, Gallant MA, de Brum-Fernandes A, and Parent JL. Oligomerization of the alpha and beta isoforms of the thromboxane A2 receptor: relevance to receptor signaling and endocytosis. Cell Signal 17 (2005 Nov): 1373-83.
16190749 PubMed
Soulier JL, Russo O, Giner M, Rivail L, Berthouze M, Ongeri S, Maigret B, Fischmeister R, Lezoualc'h F, Sicsic S, and Berque-Bestel I. Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies. J Med Chem 48 (2005 Oct 6): 6220-8.
16190749 PubMed
Soulier JL, Russo O, Giner M, Rivail L, Berthouze M, Ongeri S, Maigret B, Fischmeister R, Lezoualc'h F, Sicsic S, and Berque-Bestel I. Design and synthesis of specific probes for human 5-HT4 receptor dimerization studies. J Med Chem 48 (2005 Oct 6): 6220-8.
15923381 PubMed
So CH, Varghese G, Curley KJ, Kong MM, Alijaniaram M, Ji X, Nguyen T, O'dowd BF, and George SR. D1 and D2 dopamine receptors form heterooligomers and cointernalize after selective activation of either receptor. Mol Pharmacol 68 (2005 Sep): 568-78.
15946947 PubMed
Wilson S, Wilkinson G, and Milligan G. The CXCR1 and CXCR2 receptors form constitutive homo- and heterodimers selectively and with equal apparent affinities. J Biol Chem 280 (2005 Aug 5): 28663-74.
15863499 PubMed
Goudet C, Kniazeff J, Hlavackova V, Malhaire F, Maurel D, Acher F, Blahos J, Prezeau L, and Pin JP. Asymmetric functioning of dimeric metabotropic glutamate receptors disclosed by positive allosteric modulators. J Biol Chem 280 (2005 Jul 1): 24380-5.
15932946 PubMed
Waldhoer M, Fong J, Jones RM, Lunzer MM, Sharma SK, Kostenis E, Portoghese PS, and Whistler JL. A heterodimer-selective agonist shows in vivo relevance of G protein-coupled receptor dimers. Proc Natl Acad Sci U S A 102 (2005 Jun 21): 9050-5.
15778451 PubMed
Wang D, Sun X, Bohn LM, and Sadee W. Opioid receptor homo- and heterodimerization in living cells by quantitative bioluminescence resonance energy transfer. Mol Pharmacol 67 (2005 Jun): 2173-84.
15889138 PubMed
Urizar E, Montanelli L, Loy T, Bonomi M, Swillens S, Gales C, Bouvier M, Smits G, Vassart G, and Costagliola S. Glycoprotein hormone receptors: link between receptor homodimerization and negative cooperativity. EMBO J 24 (2005 Jun 1): 1954-64.
15746093 PubMed
Miura S, Karnik SS, and Saku K. Constitutively active homo-oligomeric angiotensin II type 2 receptor induces cell signaling independent of receptor conformation and ligand stimulation. J Biol Chem 280 (2005 May 6): 18237-44.
15710746 PubMed
Kearn CS, Blake-Palmer K, Daniel E, Mackie K, and Glass M. Concurrent stimulation of cannabinoid CB1 and dopamine D2 receptors enhances heterodimer formation: a mechanism for receptor cross-talk? Mol Pharmacol 67 (2005 May): 1697-704.
15615865 PubMed
Uberti MA, Hague C, Oller H, Minneman KP, and Hall RA. Heterodimerization with beta2-adrenergic receptors promotes surface expression and functional activity of alpha1D-adrenergic receptors. J Pharmacol Exp Ther 313 (2005 Apr): 16-23.
15593372 PubMed
Nemoto W, and Toh H. Prediction of interfaces for oligomerizations of G-protein coupled receptors. Proteins 58 (2005 Feb 15): 644-60.
15660124 PubMed
Hlavackova V, Goudet C, Kniazeff J, Zikova A, Maurel D, Vol C, Trojanova J, Prezeau L, Pin JP, and Blahos J. Evidence for a single heptahelical domain being turned on upon activation of a dimeric GPCR. EMBO J 24 (2005 Feb 9): 499-509.
15509716 PubMed
El-Asmar L, Springael JY, Ballet S, Andrieu EU, Vassart G, and Parmentier M. Evidence for negative binding cooperativity within CCR5-CCR2b heterodimers. Mol Pharmacol 67 (2005 Feb): 460-9.
15655508 PubMed
Deighan C, Methven L, Naghadeh MM, Wokoma A, Macmillan J, Daly CJ, Tanoue A, Tsujimoto G, and McGrath JC. Insights into the functional roles of alpha(1)-adrenoceptor subtypes in mouse carotid arteries using knockout mice. Br J Pharmacol 144 (2005 Feb): 558-65.
15659214 PubMed
Rodrigues RJ, Alfaro TM, Rebola N, Oliveira CR, and Cunha RA. Co-localization and functional interaction between adenosine A(2A) and metabotropic group 5 receptors in glutamatergic nerve terminals of the rat striatum. J Neurochem 92 (2005 Feb): 433-41.
15659165 PubMed
Ladds G, Davis K, Das A, and Davey J. A constitutively active GPCR retains its G protein specificity and the ability to form dimers. Mol Microbiol 55 (2005 Jan): 482-97.
15489507 PubMed
Jastrzebska B, Maeda T, Zhu L, Fotiadis D, Filipek S, Engel A, Stenkamp RE, and Palczewski K. Functional characterization of rhodopsin monomers and dimers in detergents. J Biol Chem 279 (2004 Dec 24): 54663-75.
15471868 PubMed
Wilson SJ, Roche AM, Kostetskaia E, and Smyth EM. Dimerization of the human receptors for prostacyclin and thromboxane facilitates thromboxane receptor-mediated cAMP generation. J Biol Chem 279 (2004 Dec 17): 53036-47.
15358776 PubMed
Mesnier D, and Baneres JL. Cooperative conformational changes in a G-protein-coupled receptor dimer, the leukotriene B(4) receptor BLT1. J Biol Chem 279 (2004 Nov 26): 49664-70.
15304550 PubMed
Carrillo JJ, Lopez-Gimenez JF, and Milligan G. Multiple interactions between transmembrane helices generate the oligomeric alpha1b-adrenoceptor. Mol Pharmacol 66 (2004 Nov): 1123-37.
15494033 PubMed
Zhang YQ, and Limbird LE. Hetero-oligomers of alpha2A-adrenergic and mu-opioid receptors do not lead to transactivation of G-proteins or altered endocytosis profiles. Biochem Soc Trans 32 (2004 Nov): 856-60.
15764373 PubMed
Suda K, Filipek S, Palczewski K, Engel A, and Fotiadis D. The supramolecular structure of the GPCR rhodopsin in solution and native disc membranes. Mol Membr Biol 21 (2004 Nov-Dec): 435-46.
15507206 PubMed
AbdAlla S, Lother H, Langer A, el Faramawy Y, and Quitterer U. Factor XIIIA transglutaminase crosslinks AT1 receptor dimers of monocytes at the onset of atherosclerosis. Cell 119 (2004 Oct 29): 343-54.
15362892 PubMed
Ciruela F, Burgueno J, Casado V, Canals M, Marcellino D, Goldberg SR, Bader M, Fuxe K, Agnati LF, Lluis C, Franco R, Ferre S, and Woods AS. Combining mass spectrometry and pull-down techniques for the study of receptor heteromerization. Direct epitope-epitope electrostatic interactions between adenosine A2A and dopamine D2 receptors. Anal Chem 76 (2004 Sep 15): 5354-63.
15347813 PubMed
Hague C, Uberti MA, Chen Z, Bush CF, Jones SV, Ressler KJ, Hall RA, and Minneman KP. Olfactory receptor surface expression is driven by association with the beta2-adrenergic receptor. Proc Natl Acad Sci U S A 101 (2004 Sep 14): 13672-6.
15312183 PubMed
Domenici MR, Pepponi R, Martire A, Tebano MT, Potenza RL, and Popoli P. Permissive role of adenosine A2A receptors on metabotropic glutamate receptor 5 (mGluR5)-mediated effects in the striatum. J Neurochem 90 (2004 Sep): 1276-9.
15231824 PubMed
Grant M, Collier B, and Kumar U. Agonist-dependent dissociation of human somatostatin receptor 2 dimers: a role in receptor trafficking. J Biol Chem 279 (2004 Aug 27): 36179-83.
15159403 PubMed
Lee SP, So CH, Rashid AJ, Varghese G, Cheng R, Lanca AJ, O'Dowd BF, and George SR. Dopamine D1 and D2 receptor Co-activation generates a novel phospholipase C-mediated calcium signal. J Biol Chem 279 (2004 Aug 20): 35671-8.
15155738 PubMed
Salahpour A, Angers S, Mercier JF, Lagace M, Marullo S, and Bouvier M. Homodimerization of the beta2-adrenergic receptor as a prerequisite for cell surface targeting. J Biol Chem 279 (2004 Aug 6): 33390-7.
15039773 PubMed
Coccurello R, Breysse N, and Amalric M. Simultaneous blockade of adenosine A2A and metabotropic glutamate mGlu5 receptors increase their efficacy in reversing Parkinsonian deficits in rats. Neuropsychopharmacology 29 (2004 Aug): 1451-61.
15235591 PubMed
Kniazeff J, Bessis AS, Maurel D, Ansanay H, Prezeau L, and Pin JP. Closed state of both binding domains of homodimeric mGlu receptors is required for full activity. Nat Struct Mol Biol 11 (2004 Aug): 706-13.
15266022 PubMed
Ayoub MA, Levoye A, Delagrange P, and Jockers R. Preferential formation of MT1/MT2 melatonin receptor heterodimers with distinct ligand interaction properties compared with MT2 homodimers. Mol Pharmacol 66 (2004 Aug): 312-21.
15207471 PubMed
Woolf PJ, and Linderman JJ. An algebra of dimerization and its implications for G-protein coupled receptor signaling. J Theor Biol 229 (2004 Jul 21): 157-68.
15240800 PubMed
Gassmann M, Shaban H, Vigot R, Sansig G, Haller C, Barbieri S, Humeau Y, Schuler V, Muller M, Kinzel B, Klebs K, Schmutz M, Froestl W, Heid J, Kelly PH, Gentry C, Jaton AL, Van der Putten H, Mombereau C, Lecourtier L, Mosbacher J, Cryan JF, Fritschy JM, Luthi A, Kaupmann K, and Bettler B. Redistribution of GABAB(1) protein and atypical GABAB responses in GABAB(2)-deficient mice. J Neurosci 24 (2004 Jul 7): 6086-97.
15123695 PubMed
Breit A, Lagace M, and Bouvier M. Hetero-oligomerization between beta2- and beta3-adrenergic receptors generates a beta-adrenergic signaling unit with distinct functional properties. J Biol Chem 279 (2004 Jul 2): 28756-65.
15184890 PubMed
Tateyama M, Abe H, Nakata H, Saito O, and Kubo Y. Ligand-induced rearrangement of the dimeric metabotropic glutamate receptor 1alpha. Nat Struct Mol Biol 11 (2004 Jul): 637-42.
15170495 PubMed
Filipek S, Krzysko KA, Fotiadis D, Liang Y, Saperstein DA, Engel A, and Palczewski K. A concept for G protein activation by G protein-coupled receptor dimers: the transducin/rhodopsin interface. Photochem Photobiol Sci 3 (2004 Jun): 628-38.
15111110 PubMed
Fotiadis D, Liang Y, Filipek S, Saperstein DA, Engel A, and Palczewski K. The G protein-coupled receptor rhodopsin in the native membrane. FEBS Lett 564 (2004 Apr 30): 281-8.
14736874 PubMed
Hague C, Uberti MA, Chen Z, Hall RA, and Minneman KP. Cell surface expression of alpha1D-adrenergic receptors is controlled by heterodimerization with alpha1B-adrenergic receptors. J Biol Chem 279 (2004 Apr 9): 15541-9.
15044695 PubMed
Gomes I, Gupta A, Filipovska J, Szeto HH, Pintar JE, and Devi LA. A role for heterodimerization of mu and delta opiate receptors in enhancing morphine analgesia. Proc Natl Acad Sci U S A 101 (2004 Apr 6): 5135-9.
14726491 PubMed
Ji I, Lee C, Jeoung M, Koo Y, Sievert GA, and Ji TH. Trans-activation of mutant follicle-stimulating hormone receptors selectively generates only one of two hormone signals. Mol Endocrinol 18 (2004 Apr): 968-78.
14634050 PubMed
Jarrahian A, Watts VJ, and Barker EL. D2 dopamine receptors modulate Galpha-subunit coupling of the CB1 cannabinoid receptor. J Pharmacol Exp Ther 308 (2004 Mar): 880-6.
14594799 PubMed
Tao YX, Johnson NB, and Segaloff DL. Constitutive and agonist-dependent self-association of the cell surface human lutropin receptor. J Biol Chem 279 (2004 Feb 13): 5904-14.
14716309 PubMed
Hernanz-Falcon P, Rodriguez-Frade JM, Serrano A, Juan D, del Sol A, Soriano SF, Roncal F, Gomez L, Valencia A, Martinez-A C, and Mellado M. Identification of amino acid residues crucial for chemokine receptor dimerization. Nat Immunol 5 (2004 Feb): 216-23.
14663004 PubMed
Fuxe K, Agnati LF, Jacobsen K, Hillion J, Canals M, Torvinen M, Tinner-Staines B, Staines W, Rosin D, Terasmaa A, Popoli P, Leo G, Vergoni V, Lluis C, Ciruela F, Franco R, and Ferre S. Receptor heteromerization in adenosine A2A receptor signaling: relevance for striatal function and Parkinson's disease. Neurology 61 (2003 Dec 9): S19-23.
14645661 PubMed
Jordan BA, Gomes I, Rios C, Filipovska J, and Devi LA. Functional interactions between mu opioid and alpha 2A-adrenergic receptors. Mol Pharmacol 64 (2003 Dec): 1317-24.
12933819 PubMed
Canals M, Marcellino D, Fanelli F, Ciruela F, de Benedetti P, Goldberg SR, Neve K, Fuxe K, Agnati LF, Woods AS, Ferre S, Lluis C, Bouvier M, and Franco R. Adenosine A2A-dopamine D2 receptor-receptor heteromerization: qualitative and quantitative assessment by fluorescence and bioluminescence energy transfer. J Biol Chem 278 (2003 Nov 21): 46741-9.
14535946 PubMed
Maggio R, Scarselli M, Novi F, Millan MJ, and Corsini GU. Potent activation of dopamine D3/D2 heterodimers by the antiparkinsonian agents, S32504, pramipexole and ropinirole. J Neurochem 87 (2003 Nov): 631-41.
14636554 PubMed
Zhao GQ, Zhang Y, Hoon MA, Chandrashekar J, Erlenbach I, Ryba NJ, and Zuker CS. The receptors for mammalian sweet and umami taste. Cell 115 (2003 Oct 31): 255-66.
12920117 PubMed
Carrillo JJ, Pediani J, and Milligan G. Dimers of class A G protein-coupled receptors function via agonist-mediated trans-activation of associated G proteins. J Biol Chem 278 (2003 Oct 24): 42578-87.
12888558 PubMed
Trettel F, Di Bartolomeo S, Lauro C, Catalano M, Ciotti MT, and Limatola C. Ligand-independent CXCR2 dimerization. J Biol Chem 278 (2003 Oct 17): 40980-8.
12974638 PubMed
Lee SP, O'Dowd BF, Rajaram RD, Nguyen T, and George SR. D2 dopamine receptor homodimerization is mediated by multiple sites of interaction, including an intermolecular interaction involving transmembrane domain 4. Biochemistry 42 (2003 Sep 23): 11023-31.
12835318 PubMed
Floyd DH, Geva A, Bruinsma SP, Overton MC, Blumer KJ, and Baranski TJ. C5a receptor oligomerization. II. Fluorescence resonance energy transfer studies of a human G protein-coupled receptor expressed in yeast. J Biol Chem 278 (2003 Sep 12): 35354-61.
12835319 PubMed
Klco JM, Lassere TB, and Baranski TJ. C5a receptor oligomerization. I. Disulfide trapping reveals oligomers and potential contact surfaces in a G protein-coupled receptor. J Biol Chem 278 (2003 Sep 12): 35345-53.
12756251 PubMed
Perron A, Chen ZG, Gingras D, Dupre DJ, Stankova J, and Rola-Pleszczynski M. Agonist-independent desensitization and internalization of the human platelet-activating factor receptor by coumermycin-gyrase B-induced dimerization. J Biol Chem 278 (2003 Jul 25): 27956-65.
12663652 PubMed
Liang Y, Fotiadis D, Filipek S, Saperstein DA, Palczewski K, and Engel A. Organization of the G protein-coupled receptors rhodopsin and opsin in native membranes. J Biol Chem 278 (2003 Jun 13): 21655-62.
12787680 PubMed
Baneres JL, and Parello J. Structure-based analysis of GPCR function: evidence for a novel pentameric assembly between the dimeric leukotriene B4 receptor BLT1 and the G-protein. J Mol Biol 329 (2003 Jun 13): 815-29.
12554793 PubMed
Terrillon S, Durroux T, Mouillac B, Breit A, Ayoub MA, Taulan M, Jockers R, Barberis C, and Bouvier M. Oxytocin and vasopressin V1a and V2 receptors form constitutive homo- and heterodimers during biosynthesis. Mol Endocrinol 17 (2003 Apr): 677-91.
12529373 PubMed
Xu J, He J, Castleberry AM, Balasubramanian S, Lau AG, and Hall RA. Heterodimerization of alpha 2A- and beta 1-adrenergic receptors. J Biol Chem 278 (2003 Mar 21): 10770-7.
12496294 PubMed
Guo W, Shi L, and Javitch JA. The fourth transmembrane segment forms the interface of the dopamine D2 receptor homodimer. J Biol Chem 278 (2003 Feb 14): 4385-8.
12538871 PubMed
Nishi A, Liu F, Matsuyama S, Hamada M, Higashi H, Nairn AC, and Greengard P. Metabotropic mGlu5 receptors regulate adenosine A2A receptor signaling. Proc Natl Acad Sci U S A 100 (2003 Feb 4): 1322-7.
12393857 PubMed
Hanyaloglu AC, Seeber RM, Kohout TA, Lefkowitz RJ, and Eidne KA. Homo- and hetero-oligomerization of thyrotropin-releasing hormone (TRH) receptor subtypes. Differential regulation of beta-arrestins 1 and 2. J Biol Chem 277 (2002 Dec 27): 50422-30.
12244098 PubMed
Mercier JF, Salahpour A, Angers S, Breit A, and Bouvier M. Quantitative assessment of beta 1- and beta 2-adrenergic receptor homo- and heterodimerization by bioluminescence resonance energy transfer. J Biol Chem 277 (2002 Nov 22): 44925-31.
12194975 PubMed
Overton MC, and Blumer KJ. The extracellular N-terminal domain and transmembrane domains 1 and 2 mediate oligomerization of a yeast G protein-coupled receptor. J Biol Chem 277 (2002 Nov 1): 41463-72.
12538907 PubMed
Filizola M, Olmea O, and Weinstein H. Prediction of heterodimerization interfaces of G-protein coupled receptors with a new subtractive correlated mutation method. Protein Eng 15 (2002 Nov): 881-5.
12270132 PubMed
He J, Xu J, Castleberry AM, Lau AG, and Hall RA. Glycosylation of beta(1)-adrenergic receptors regulates receptor surface expression and dimerization. Biochem Biophys Res Commun 297 (2002 Sep 27): 565-72.
12189203 PubMed
Ferre S, Karcz-Kubicha M, Hope BT, Popoli P, Burgueno J, Gutierrez MA, Casado V, Fuxe K, Goldberg SR, Lluis C, Franco R, and Ciruela F. Synergistic interaction between adenosine A2A and glutamate mGlu5 receptors: implications for striatal neuronal function. Proc Natl Acad Sci U S A 99 (2002 Sep 3): 11940-5.
12217648 PubMed
Overton MC, and Blumer KJ. Use of fluorescence resonance energy transfer to analyze oligomerization of G-protein-coupled receptors expressed in yeast. Methods 27 (2002 Aug): 324-32.
12217650 PubMed
Patel RC, Lange DC, and Patel YC. Photobleaching fluorescence resonance energy transfer reveals ligand-induced oligomer formation of human somatostatin receptor subtypes. Methods 27 (2002 Aug): 340-8.
11971762 PubMed
Ramsay D, Kellett E, McVey M, Rees S, and Milligan G. Homo- and hetero-oligomeric interactions between G-protein-coupled receptors in living cells monitored by two variants of bioluminescence resonance energy transfer (BRET): hetero-oligomers between receptor subtypes form more efficiently than between less closely related sequences. Biochem J 365 (2002 Jul 15): 429-40.
12040016 PubMed
Ji I, Lee C, Song Y, Conn PM, and Ji TH. Cis- and trans-activation of hormone receptors: the LH receptor. Mol Endocrinol 16 (2002 Jun): 1299-308.
11896051 PubMed
Pfeiffer M, Koch T, Schroder H, Laugsch M, Hollt V, and Schulz S. Heterodimerization of somatostatin and opioid receptors cross-modulates phosphorylation, internalization, and desensitization. J Biol Chem 277 (2002 May 31): 19762-72.
11872740 PubMed
Hillion J, Canals M, Torvinen M, Casado V, Scott R, Terasmaa A, Hansson A, Watson S, Olah ME, Mallol J, Canela EI, Zoli M, Agnati LF, Ibanez CF, Lluis C, Franco R, Ferre S, and Fuxe K. Coaggregation, cointernalization, and codesensitization of adenosine A2A receptors and dopamine D2 receptors. J Biol Chem 277 (2002 May 17): 18091-7.
11988350 PubMed
Diaz-Cabiale Z, Vivo M, Del Arco A, O'Connor WT, Harte MK, Muller CE, Martinez E, Popoli P, Fuxe K, and Ferre S. Metabotropic glutamate mGlu5 receptor-mediated modulation of the ventral striopallidal GABA pathway in rats. Interactions with adenosine A(2A) and dopamine D(2) receptors. Neurosci Lett 324 (2002 May 17): 154-8.
11854302 PubMed
Salim K, Fenton T, Bacha J, Urien-Rodriguez H, Bonnert T, Skynner HA, Watts E, Kerby J, Heald A, Beer M, McAllister G, and Guest PC. Oligomerization of G-protein-coupled receptors shown by selective co-immunoprecipitation. J Biol Chem 277 (2002 May 3): 15482-5.
11917125 PubMed
Li X, Staszewski L, Xu H, Durick K, Zoller M, and Adler E. Human receptors for sweet and umami taste. Proc Natl Acad Sci U S A 99 (2002 Apr 2): 4692-6.
11867751 PubMed
Tsuchiya D, Kunishima N, Kamiya N, Jingami H, and Morikawa K. Structural views of the ligand-binding cores of a metabotropic glutamate receptor complexed with an antagonist and both glutamate and Gd3+. Proc Natl Acad Sci U S A 99 (2002 Mar 5): 2660-5.
11793427 PubMed
Glass MJ, and Pickel VM. Alpha(2A)-adrenergic receptors are present in mu-opioid receptor containing neurons in rat medial nucleus tractus solitarius. Synapse 43 (2002 Mar 1): 208-18.
12539260 PubMed
Filizola M, and Weinstein H. Structural models for dimerization of G-protein coupled receptors: the opioid receptor homodimers. Biopolymers 66 (2002): 317-25.
11673456 PubMed
Cheng ZJ, and Miller LJ. Agonist-dependent dissociation of oligomeric complexes of G protein-coupled cholecystokinin receptors demonstrated in living cells using bioluminescence resonance energy transfer. J Biol Chem 276 (2001 Dec 21): 48040-7.
11846559 PubMed
Davies A, Gowen BE, Krebs AM, Schertler GF, and Saibil HR. Three-dimensional structure of an invertebrate rhodopsin and basis for ordered alignment in the photoreceptor membrane. J Mol Biol 314 (2001 Nov 30): 455-63.
11557164 PubMed
Popoli P, Pezzola A, Torvinen M, Reggio R, Pintor A, Scarchilli L, Fuxe K, and Ferre S. The selective mGlu(5) receptor agonist CHPG inhibits quinpirole-induced turning in 6-hydroxydopamine-lesioned rats and modulates the binding characteristics of dopamine D(2) receptors in the rat striatum: interactions with adenosine A(2a) receptors. Neuropsychopharmacology 25 (2001 Oct): 505-13.
11533702 PubMed
AbdAlla S, Lother H, el Massiery A, and Quitterer U. Increased AT(1) receptor heterodimers in preeclampsia mediate enhanced angiotensin II responsiveness. Nat Med 7 (2001 Sep): 1003-9.
11373283 PubMed
Scarselli M, Novi F, Schallmach E, Lin R, Baragli A, Colzi A, Griffon N, Corsini GU, Sokoloff P, Levenson R, Vogel Z, and Maggio R. D2/D3 dopamine receptor heterodimers exhibit unique functional properties. J Biol Chem 276 (2001 Aug 10): 30308-14.
11509186 PubMed
Nelson G, Hoon MA, Chandrashekar J, Zhang Y, Ryba NJ, and Zuker CS. Mammalian sweet taste receptors. Cell 106 (2001 Aug 10): 381-90.
11435907 PubMed
Diaz-Cabiale Z, Hurd Y, Guidolin D, Finnman UB, Zoli M, Agnati LF, Vanderhaeghen JJ, Fuxe K, and Ferre S. Adenosine A2A agonist CGS 21680 decreases the affinity of dopamine D2 receptors for dopamine in human striatum. Neuroreport 12 (2001 Jul 3): 1831-4.
11378162 PubMed
Meschler JP, and Howlett AC. Signal transduction interactions between CB1 cannabinoid and dopamine receptors in the rat and monkey striatum. Neuropharmacology 40 (2001 Jun): 918-26.
11414794 PubMed
Prosser HM, Gill CH, Hirst WD, Grau E, Robbins M, Calver A, Soffin EM, Farmer CE, Lanneau C, Gray J, Schenck E, Warmerdam BS, Clapham C, Reavill C, Rogers DC, Stean T, Upton N, Humphreys K, Randall A, Geppert M, Davies CH, and Pangalos MN. Epileptogenesis and enhanced prepulse inhibition in GABA(B1)-deficient mice. Mol Cell Neurosci 17 (2001 Jun): 1059-70.
11278325 PubMed
Ciruela F, Escriche M, Burgueno J, Angulo E, Casado V, Soloviev MM, Canela EI, Mallol J, Chan WY, Lluis C, McIlhinney RA, and Franco R. Metabotropic glutamate 1alpha and adenosine A1 receptors assemble into functionally interacting complexes. J Biol Chem 276 (2001 May 25): 18345-51.
11331581 PubMed
Galvez T, Duthey B, Kniazeff J, Blahos J, Rovelli G, Bettler B, Prezeau L, and Pin JP. Allosteric interactions between GB1 and GB2 subunits are required for optimal GABA(B) receptor function. EMBO J 20 (2001 May 1): 2152-9.
11278883 PubMed
Kroeger KM, Hanyaloglu AC, Seeber RM, Miles LE, and Eidne KA. Constitutive and agonist-dependent homo-oligomerization of the thyrotropin-releasing hormone receptor. Detection in living cells using bioluminescence resonance energy transfer. J Biol Chem 276 (2001 Apr 20): 12736-43.
11358333 PubMed
Angers S, Salahpour A, and Bouvier M. Biochemical and biophysical demonstration of GPCR oligomerization in mammalian cells. Life Sci 68 (2001 Apr 6): 2243-50.
11134510 PubMed
Jordan BA, Trapaidze N, Gomes I, Nivarthi R, and Devi LA. Oligomerization of opioid receptors with beta 2-adrenergic receptors: a role in trafficking and mitogen-activated protein kinase activation. Proc Natl Acad Sci U S A 98 (2001 Jan 2): 343-8.
11069979 PubMed
Gomes I, Jordan BA, Gupta A, Trapaidze N, Nagy V, and Devi LA. Heterodimerization of mu and delta opioid receptors: A role in opiate synergy. J Neurosci 20 (2000 Nov 15): RC110.
11069170 PubMed
Kunishima N, Shimada Y, Tsuji Y, Sato T, Yamamoto M, Kumasaka T, Nakanishi S, Jingami H, and Morikawa K. Structural basis of glutamate recognition by a dimeric metabotropic glutamate receptor. Nature 407 (2000 Oct 26): 971-7.
10842167 PubMed
George SR, Fan T, Xie Z, Tse R, Tam V, Varghese G, and O'Dowd BF. Oligomerization of mu- and delta-opioid receptors. Generation of novel functional properties. J Biol Chem 275 (2000 Aug 25): 26128-35.
10725388 PubMed
Angers S, Salahpour A, Joly E, Hilairet S, Chelsky D, Dennis M, and Bouvier M. Detection of beta 2-adrenergic receptor dimerization in living cells using bioluminescence resonance energy transfer (BRET). Proc Natl Acad Sci U S A 97 (2000 Mar 28): 3684-9.
10744981 PubMed
Overton MC, and Blumer KJ. G-protein-coupled receptors function as oligomers in vivo. Curr Biol 10 (2000 Mar 23): 341-4.
10490911 PubMed
Maggio R, Barbier P, Colelli A, Salvadori F, Demontis G, and Corsini GU. G protein-linked receptors: pharmacological evidence for the formation of heterodimers. J Pharmacol Exp Ther 291 (1999 Oct): 251-7.
10193904 PubMed
Ferre S, Popoli P, Rimondini R, Reggio R, Kehr J, and Fuxe K. Adenosine A2A and group I metabotropic glutamate receptors synergistically modulate the binding characteristics of dopamine D2 receptors in the rat striatum. Neuropharmacology 38 (1999 Jan): 129-40.
9872315 PubMed
Jones KA, Borowsky B, Tamm JA, Craig DA, Durkin MM, Dai M, Yao WJ, Johnson M, Gunwaldsen C, Huang LY, Tang C, Shen Q, Salon JA, Morse K, Laz T, Smith KE, Nagarathnam D, Noble SA, Branchek TA, and Gerald C. GABA(B) receptors function as a heteromeric assembly of the subunits GABA(B)R1 and GABA(B)R2. Nature 396 (1998 Dec 17): 674-9.
9872316 PubMed
White JH, Wise A, Main MJ, Green A, Fraser NJ, Disney GH, Barnes AA, Emson P, Foord SM, and Marshall FH. Heterodimerization is required for the formation of a functional GABA(B) receptor. Nature 396 (1998 Dec 17): 679-82.
9872317 PubMed
Kaupmann K, Malitschek B, Schuler V, Heid J, Froestl W, Beck P, Mosbacher J, Bischoff S, Kulik A, Shigemoto R, Karschin A, and Bettler B. GABA(B)-receptor subtypes assemble into functional heteromeric complexes. Nature 396 (1998 Dec 17): 683-7.
9312107 PubMed
Osuga Y, Hayashi M, Kudo M, Conti M, Kobilka B, and Hsueh AJ. Co-expression of defective luteinizing hormone receptor fragments partially reconstitutes ligand-induced signal generation. J Biol Chem 272 (1997 Oct 3): 25006-12.
9278550 PubMed
Stone LS, MacMillan LB, Kitto KF, Limbird LE, and Wilcox GL. The alpha2a adrenergic receptor subtype mediates spinal analgesia evoked by alpha2 agonists and is necessary for spinal adrenergic-opioid synergy. J Neurosci 17 (1997 Sep 15): 7157-65.
8385357 PubMed
Maggio R, Vogel Z, and Wess J. Coexpression studies with mutant muscarinic/adrenergic receptors provide evidence for intermolecular "cross-talk" between G-protein-linked receptors. Proc Natl Acad Sci U S A 90 (1993 Apr 1): 3103-7.
15911136 PubMed
Zhang ZJ, Jiang XL, Zhang SE, Hough CJ, Li H, Chen JG, and Zhen XC. The paradoxical effects of SKF83959, a novel dopamine D1-like receptor agonist, in the rat acoustic startle reflex paradigm. Neurosci Lett 382 (2005 Jul 1-8): 134-8.
Export to TSV


References:

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M.

GPCR-OKB: The G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 May 25. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. doi:10.1093/bioinformatics/btq264