GPCR-OKB Abbreviations

The G Protein Coupled Receptor -
Oligomerization Knowledge Base Project

If checked, GPCR-OKB will search for Oligomers.

Please specify the name of the oligomer of interest made up of the names of the protomers that form its constituent parts. The "Oligomer" option is checked by default.

Example: If you would like to retrieve information about an oligomer of the dopamine D2 receptor, you can either write "dopamine" or "D2".

If you select the "With Phenotypic Changes" option, you will limit your search to only oligomers with demonstrated phenotypic changes.

If you select the "With Proposed Interfaces" option, you can retrieve available information about predicted interfaces of dimerization/oligomerization.

If you select the "With In Vivo Evidence" option, you will limit your search to Oligomers for which at least one of the following 3 criteria are satisfied: 1) Evidence for physical association in native tissue or primary cells; 2) Identification of specific functional property in native tissue; 3) Use of knockout animals or RNAi technology. These criteria are NC-IUPHAR recommendations to recognize a bona fide functional GPCR oligomer, and were reported in detail in Pin J-P, et al., International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers. Pharmacological Reviews 2007, 59(1):1-9.

If you select the "Evidence for Physiological Relevance" option, you will limit your search to Oligomers for which at least two of the following 3 criteria are satisfied: 1) Evidence for physical association in native tissue or primary cells; 2) Identification of specific functional property in native tissue; 3) Use of knockout animals or RNAi technology. These criteria are NC-IUPHAR recommendations to recognize a bona fide functional GPCR oligomer, and were reported in detail in Pin J-P, et al., International Union of Basic and Clinical Pharmacology. LXVII. Recommendations for the Recognition and Nomenclature of G Protein-Coupled Receptor Heteromultimers. Pharmacological Reviews 2007, 59(1):1-9.

Find Oligomers
          With Phenotypic Changes
          With Proposed Interfaces
          With In Vivo Evidence
          With Evidence for Physiological Relevance

If checked, GPCR-OKB will search for Protomers (i.e., constituent subunits of an Oligomer).

Please specify the name of any receptor protomer in the oligomer.

Example: If you would like to retrieve information about dopamine D2 receptor, you can either write "D2" or "dopamine".

Find Protomers

If checked, GPCR-OKB will search for Methods.

Please specify a method type used for the discovery and/or characterization of GPCR oligomers.

Example: If you would like to retrieve information about all oligomers identified by FRET studies, please write "FRET".

Find Methods

Boolean Operators
and	Specifies this term MUST be in the search results - this is the default operator
or	Specifies this term MAY be in the search results
not	Specifies this term MUST-NOT be in the search results

Search Term Modifiers
*	(Wildcard) Can be placed at the front and/or at the end of a search term to find partial term matches
~	(Regular Expression) Can be placed at the front of a search term to search using a regular expression

Special Notes
GPCR-OKB searches are always case-insensitive Any boolean operators provided should be preceding and connected to the term they operate on, for example use +cat not + cat (the extra space between + and cat will not work as desired) GPCR-OKB does not support phrasal or proximity searches

Examples
m1 or m2	Search for items containing the terms m1 or m2
m1 m2	Searches m1 and m2, as "and" is the default search operator
protein not m1 not m2	Search for items with the term protein but not the terms m1 or m2
rotei m2	Search for items which have a term that contains the string 'rotei' and the term m2
adenos* not *a	Search for items which have a term that starts with the string 'adenos' but no terms that end with the string 'a'

Abbreviations

Family	Ligand	Official IUPHAR name	Human gene name

CLASS A
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT1A	HTR1A
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT1B	HTR1B
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT1D	HTR1D
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT2A	HTR2A
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT2C	HTR2C
5-Hydroxytryptamine receptors	5-hydroxytryptamine	5-HT4	HTR4
Acetylcholine receptors (muscarinic)	acetylcholine	M3	CHRM3
Adenosine receptors	adenosine	A1	ADORA1
Adenosine receptors	adenosine	A2A	ADORA2A
Adrenoceptors	adrenaline	alpha1B-adrenoceptor	ADRA1B
Adrenoceptors	adrenaline	alpha1D-adrenoceptor	ADRA1D
Adrenoceptors	adrenaline	alpha2A-adrenoceptor	ADRA2A
Adrenoceptors	noradrenaline	beta1-adrenoceptor	ADRB1
Adrenoceptors	adrenaline	beta2-adrenoceptor	ADRB2
Anaphylatoxin receptors	anaphylatoxin C5a	C5a	C5R1
Angiotensin receptors	angiotensin	AT2	AGTR1
Angiotensin receptors	angiotensin	AT2	AGTR2
Bradykinin receptors	bradykinin	B1	BDKRB1
Bradykinin receptors	bradykinin	B2	BDKRB2
Cannabinoid receptors	cannabinoid	CB1	CNR1
Cannabinoid receptors	cannabinoid	CB2	CNR2
Chemokine receptors	CCL2, CCL7, CCL8, CCL13	CCR2	CCR2
Chemokine receptors	CCL3, CCL4, CCL5, CCL8, CCL14	CCR5	CCR5
Chemokine receptors	CXCL1-3, CXCL5-8, macrophage derived lectin	CXCR2	IL8RB
Chemokine receptors	CXCL12	CXCR4	CXCR4
Cholecystokinin receptors	cholecystokinin	CCK1	CCKAR
Dopamine receptors	dopamine	D1	DRD1
Dopamine receptors	dopamine	D2	DRD2
Dopamine receptors	dopamine	D3	DRD3
Histamine receptors	histamine	H1	HRH1
Histamine receptors	histamine	H3	HRH3
Leukotriene receptors	leukotriene B₄	BLT1	LTB4R
Melanocortin receptors	α-melanocyte stimulating hormone	MC1	MC1R
Melatonin receptors	melatonin	MT1	MTNR1A
Melatonin receptors	melatonin	MT2	MTNR1B
Neurotensin receptors	neurotensin	NTS1	NTSR1
Opioid receptors	β-endorphin	delta	OPRD1
Opioid receptors	dynorphin A	kappa	OPRK1
Opioid receptors	β-endorphin	mu	OPRM1
Orexin receptors	orexin A, orexin B	OX1	HCRTR1
Platelet-activating factor receptor	platelet-activating factor	PAF	PTAFR
Prostanoid receptors	thromboxane A₂	TP	TBXA2R
Somatostatin receptors	somatostatin	sst1	SSTR1
Somatostatin receptors	somatostatin	sst2	SSTR2
Somatostatin receptors	somatostatin	sst5	SSTR5
Thyrotropin-releasing hormone receptor	thyrotropin-releasing hormone	TRH1	TRHR
Vasopressin and oxytocin receptors	vasopressin	V1A	AVPR1A
Vasopressin and oxytocin receptors	vasopressin	V1B	AVPR1B
Vasopressin and oxytocin receptors	vasopressin	V2	AVPR2
Vasopressin and oxytocin receptors	oxytocin	OT	OXTR
Class A Orphans		GPR26	GPR26
Non-signalling 7TM chemokine-binding proteins		CCPB2	CCBP2
Non-signalling 7TM chemokine-binding proteins		CCRL1	CCRL1
Non-signalling 7TM chemokine-binding proteins		FY	DARC

CLASS B
Calcitonin receptors	adrenomedullin, CGRP	CALCRL	CALCRL
Glucagon receptor family	secretin	STCR	SCTR

CLASS C
Calcium-sensing receptors	Calcium	CaS	CASR
Calcium-sensing receptors		GPRC6	GPRC6A
GABAB receptors	GABA	GABAB1	GABBR1
GABAB receptors		GABAB2	GABBR2
Metabotropic glutamate receptors	Glutamate	mGlu1	GRM1
Metabotropic glutamate receptors	Glutamate	mGlu2	GRM2
Metabotropic glutamate receptors	Glutamate	mGlu5	GRM5

References:

Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M.

GPCR-OKB: The G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 May 25. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. doi:10.1093/bioinformatics/btq264

The G Protein Coupled Receptor -Oligomerization Knowledge Base Project

Abbreviations

The G Protein Coupled Receptor -
Oligomerization Knowledge Base Project