The G Protein Coupled Receptor -
The GPCR-OKB is an information management system that allows browsing, visualization, and structured querying of computational and experimental information about G Protein-Coupled Receptor (GPCR) oligomerization, thus supporting productive and quantitative communication between computational and experimental scientists working in the field.
Although many biochemical and biophysical data are consistent with the ability of monomeric receptors to activate heterotrimeric G-proteins, more and more experimental evidence indicates that GPCRs can self-associate and/or interact with other GPCRs. For simplicity, GPCR-OKB will refer to GPCR oligomers, although the majority of the reported studies do not discriminate between dimers, tetramers, or higher-order oligomers.
Database content as of November 2012
Number of Oligomers: 145
Number of Protomers: 144
Number of Methods: 20
Number of Pubmed Articles: 221
GPCR-OKB Application Version Mar 7, 2012 10:31 AM EST
Requirements and ontology for a G protein-coupled receptor oligomerization knowledge base. BMC Bioinformatics. 2007 May 30;8:177. Skrabanek L, Murcia M, Bouvier M, Devi L, George SR, Lohse MJ, Milligan G, Neubig R, Palczewski K, Parmentier M, Pin JP, Vriend G, Javitch JA, Campagne F, Filizola M.
GPCR-OKB: The G Protein Coupled Receptor Oligomer Knowledge Base. Bioinformatics. 2010 May 25. Khelashvili G, Dorff K, Shan J, Camacho-Artacho M, Skrabanek L, Vroling B, Bouvier M, Devi LA, George SR, Javitch JA, Lohse MJ, Milligan G, Neubig RR, Palczewski K, Parmentier M, Pin JP, Vriend G, Campagne F, Filizola M. doi:10.1093/bioinformatics/btq264